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. 2021 Jul 21;218(9):e20210571. doi: 10.1084/jem.20210571

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© 2021 Vendramin et al.

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Figure 7. — Sensitivity to tetracyclines is dictated by ISR. (A) Western blotting of Mel-006 (BRAF^V600E) PDX tumors collected right before the start of the treatment (T₀) or at the end of the experiment (T_end) after receiving a daily dose of DT or DTT. (B) Western blotting of Mel-015 (BRAF^V600E) PDX tumors collected right before the start of the treatment (T₀) or at the end of the experiment (T_end) after receiving a daily dose of DT, DTT, or dabrafenib + trametinib with the addition of tigecycline at MRD (DT + T). •, eIF2α-Phospho band. (C) Caspase counts per image in a panel of cell lines treated with doxycycline (Doxy, 50 µM) ± ISRIB (200 nM) for 72 h. Data are mean ± SEM of three or more different biological replicates. NS, P > 0.05; *, P < 0.05; **, P < 0.01 by Student’s t test.