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Mechanism of action and synthesis process of Lf-PEG-AuNP enabling PTT therapy in GBM tissue in the brain after oral absorption. (a) Schematic illustration for oral absorption and GBM targeting of Lf-PEG-AuNP through LfR pathway of the small intestine, the BBB barrier, and GBM cells. (b) Synthetic procedure of Lf-PEG-AuNP via a PEG linker between Lf protein and AuNP.
