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. 2021 Jun 28;8:35–48. doi: 10.1016/j.bioactmat.2021.06.026

Fig. 5.

Fig. 5

Intracellular accumulation and therapeutic effect of Lf-PEG-AuNP to GBM cells after PTT laser irradiation. (a) A schematic illustration for experimental strategy of PTT effect of Lf-PEG-AuNP accumulated in the GBM cell. (b) TEM images of GBM cells treated with AuNP and Lf-PEG-AuNP for 18 h. Insert image: magnified image of square area. Yellow arrow: aggregated AuNP in the GBM cells. Orange arrows: Lf-PEG-AuNP through LfR endocytosis. L: lysosome, V: vesicles in the cytoplasm, N: nucleus. Scale bar: 500 nm. (c) Morphology of GBM cells after PTT laser irradiation for 5 min. Magnification: × 200. Scale bar: 250 μm. (d) The viability of GBM cells after PTT laser irradiation for 5 min. Data were expressed as means ± SEM (n = 5). ***P < 0.001. (d) The viability of GBM cells after 18 h treatment of each group. Data were expressed as means ± SEM (n = 5). *P < 0.05. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)