Fig. 7.

Oral absorption and GBM targeting of Lf-PEG-AuNP in orthotopic GBM-bearing mice in vivo. (a) Schematic illustration of orthotopic GBM modeling and sampling of blood and tissues. (b) TEM images of the small intestine at 2.5 h after oral administration of Lf-PEG-AuNP. Insert image: magnified image of square area. Orange arrows: Lf-PEG-AuNP. Scale bar: 500 nm. (c) Quantification of AuNP (black bar) and Lf-PEG-AuNP (gray bar) in the intestine at 24 h after oral administration. Data were expressed as means ± SEM (n = 5). *P < 0.01. (d) Quantification of AuNP (black bar) and Lf-PEG-AuNP (gray bar) in blood samples at each time after oral administration. Data were expressed as means ± SEM (n = 5). **P < 0.01. (e) TEM images of periphery and central of GBM tissue in the brain at 24 h after oral administration of Lf-PEG-AuNP. Insert image: magnified image of square area. Orange arrows: Lf-PEG-AuNP. Scale bar: 500 nm. (f) Quantification of AuNP (black bar) and Lf-PEG-AuNP (gray bar) in the small intestine and the GBM tissue in the brain 24 h after oral administration. Data were expressed as means ± SEM (n = 5). *P < 0.05. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)