Figure 3.

Hormonal responses during the hypoglycemic experimental period. Hepatic sinusoidal plasma glucagon (A), arterial glucagon (B), arterial cortisol (C), arterial plasma epinephrine (D), and norepinephrine (norepi; E) levels during the experimental period in NG, HG, and HG-HeadEu groups. HG, intraportal (Po) infusion of fructose was used to stimulate hepatic glucose uptake; NG, saline was infused Po to maintain liver glycogen levels close to a normal, fasting level; HG-HeadEu, subset of HG group in which brain euglycemia was maintained by infusing glucose bilaterally into the carotid and vertebral arteries. *P < 0.05, HG compared with NG. #P < 0.05, HG-HeadEu compared with NG. Data were analyzed using two-way repeated measures ANOVA.