Table 1.

Metabolic parameters at the end of the glycogen manipulation period (i.e., minute −120)

Group	Arterial Plasma Glucose, mg/dL	Arterial Plasma Insulin, µU/mL	Hepatic Sinusoidal Insulin, µU/mL	Arterial Plasma Glucagon, pg/mL	Hepatic Sinusoidal Glucagon, pg/mL	Total Hepatic Blood Flow, mL/kg/min	Net Hepatic Glucose Uptake, mg/kg/min
NG	210 ± 2	7.9 ± 0.4	26 ± 2	24 ± 3	35 ± 3	26 ± 2	1.8 ± 0.5
HG	217 ± 3	8.1 ± 1.1	23 ± 4	29 ± 3	41 ± 5	25 ± 2	7.6 ± 0.3*
HG-HeadEu	218 ± 3	7.7 ± 0.6	21 ± 2	23 ± 4	36 ± 4	26 ± 1	8.0 ± 0.7*

HG, intraportal (Po) infusion of fructose was used to stimulate hepatic glucose uptake; NG, saline was infused Po to maintain liver glycogen levels close to a normal, fasting level; HG-HeadEu, subset of HG group in which brain euglycemia was maintained by infusing glucose bilaterally into the carotid and vertebral arteries. *P < 0.05, compared with NG.