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. 2021 Apr 30;320(6):H2283–H2294. doi: 10.1152/ajpheart.00798.2020

Figure 1.

Figure 1.

A: baseline contractile pattern of paced Langendorff-perfused hearts. Fibroblast growth factor 23 (FGF23) induced abnormal contractile patterns as shown in (B). Premature ventricular beats (PVBs), defined as a new contraction before complete relaxation. C: PVB in bigeminy defined as at least two PVBs separated by one normal contraction. D: ventricular tachycardia defined as at least four PVBs without an intervening normal contraction. Average number of PVB per minute (E) and maximum number of PVBs per minute in vehicle, FGF23, and FGF23 + anti-FGFR4 groups (F). Average number of instances of bigeminy per minute (G) and incidence of bigeminy in hearts treated with vehicle, FGF23, or FGF23 + anti-FGFR4 (H). Average number of instances of ventricular tachycardia (Vtach) per minute (I) and incidence of Vtach in hearts treated with vehicle, FGF23, or FGF23 + anti-FGFR4 (J). n = 11 vehicle, n = 11 FGF23, n = 8 FGF23 + anti-FGFR4; **P < 0.01, *P < 0.05 compared with vehicle.