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Hazard ratios (and their 95% confidence intervals) measuring the time-dependent effect of risk-reducing salpingo oophorectomy (RRSO) on BC risks based on different TVC models (Cox and Oakes (red), exponential decay (blue), and permanent exposure (black)) in BRCA1 families from the BCFR; best TVC model for BRCA1 families is Cox and Oakes model (red).
