Table 5.
Penetrance estimates and their 95% confidence intervals based on the best TVC model for the BRCA1 families from the BCFR.
| Age 50 | Age 70 | |
|---|---|---|
| Breast cancera | ||
| Carriersb | 33.4% (30.6, 37.3) | 61.0% (57.2, 66.0) |
| Non-carriersb | 4.5% (3.6, 5.5) | 12.0% (9.9, 14.2) |
| RRSOc at 30 years | 24.4% (17.5, 33.5) | 49.0% (36.7, 62.3) |
| RRSOc at 35 years | 25.3% (19.6, 32.5) | 49.6% (38.3, 61.6) |
| RRSOc at 40 years | 26.8% (22.4, 32.5) | 50.5% (40.6, 61.4) |
| +MS at 35 years | 35.6% (29.6, 43.9) | 61.2% (49.9, 73.4) |
| +MS at 35 and 40 years | 32.3% (26.1, 43.5) | 52.6% (38.9, 71.6) |
| +MS at 35, 40, and 45 years | 32.9% (26.1, 43.5) | 47.9% (33.2, 73.1) |
| RRSOc at 50 years | 33.4% (30.6, 37.3) | 53.4% (46.9, 61.3) |
| +MS at 35 years | 43.2% (38.0, 51.2) | 64.1% (55.8, 74.2) |
| +MS at 35 and 40 years | 42.5% (34.5, 57.8) | 57.9% (44.8, 75.7) |
| +MS at 35, 40, and 45 years | 43.2% (34.5, 57.8) | 54.4% (40.2, 74.8) |
| Ovarian cancerd | ||
| Carriers | 4.7% (3.9, 6.0) | 11.2% (9.1, 14.2) |
| Non-carriers | 1.4% (1.0, 1.9) | 5.0% (3.9, 6.6) |
+MS: mammography screening(s) in addition to RRSO.
aCorresponds to a first breast cancer.
bCorresponds to women without RRSO or MS.
cCorresponds to women without MS.
dCorresponds to a first ovarian cancer.