Fig. 4.

Structures of SARS-CoV-2 spike (S) in complex with receptor-binding domain (RBD)-targeting monoclonal antibodies (mAbs) with neutralizing activity (nAbs). a–e Cryo-EM structures of the SARS-CoV-2 S trimer bound to nAbs. a 2-4 with all three RBDs in the down conformation (PDB 6XEY), b P5A-1B9 with one RBD in the up conformation (PDB 7CZX), c P5A-3C12 with one or two RBDs in the up conformation, respectively (PDBs 7D0B and 7D0D), d P5A-2G7 with two RBDs in the up conformation (PDB 7CZW), and e P5A-1B8 with two or three RBDs in the up conformation, respectively (PDBs 7CZR and 7CZS). f–j Crystal structures of the SARS-CoV-2 RBD in complex with the nAbs f CT-P59 (PDB 7CM4), g CV07-270 (PDB 6XKP), h P2B-2F6 (PDB 7BWJ), i CV30 (PDB 6XE1), and j CB6 (PDB 7C01)