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. 2021 Jun 25;246(17):1869–1883. doi: 10.1177/15353702211023473

Figure 5.

Figure 5.

Downregulation of KDM1A or KDM3A significantly impaired tumor growth in vivo. (a) KDM1A shRNA successfully downregulated the mRNA (upper) and protein (lower) expression of KDM1A in Panc-1 cell, n = 3. (b) Panc-1 cells with stable transfection of KDM1A shRNA or control were subcutaneously injected into nude mice. After one month, the mice were sacrificed. The knockdown of KDM1A markedly inhibited tumor group in vivo. (c) The tumors were collected and the sizes of tumors in KDM1A shRNA group were much smaller than the scrambled group. (d) IHC staining of Ki67 in samples from both groups. (e) KDM3A shRNA successfully downregulated the mRNA (upper) and protein (lower) expression of KDM3A in Panc-1 cell, n = 3. (f) Panc-1 cells with transfection of KDM3A shRNA or control were subcutaneously injected into nude mice. The knockdown of KDM3A markedly inhibited tumor group in vivo. (g) The sizes of tumor were evidently smaller than the control group. (h) IHC staining of Ki67 in KDM3A knockdown or control group. ***P < 0.001; Scramble, scrambled control. Scale bars correspond to 50 μm. (A color version of this figure is available in the online journal.)