REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Mouse anti-phosphorylated tau (AT8)	Thermo Fisher Scientific	Cat# MN1020; RRID: AB_223647
Rabbit anti-tau	Abcam	Cat# ab32057; RRID: AB_778254
Mouse anti-phosphorylated tau (AT180)	Thermo Fisher Scientific	Cat# MN1040; RRID: AB_223649
Mouse anti-β-actin	Insight Biotechnology	Cat# GTX629630; RRID: AB_2728646
IRDye 800CW goat anti-mouse IgG	Li-Cor Biosciences	P/N 926-32210; RRID: AB_621842
IRDye 680LT donkey anti-rabbit IgG	Li-Cor Biosciences	P/N 926-68023; RRID: AB_10706167
Bacterial and virus strains
Adeno-associated virus for channelrhodopsin-2 expression - pAAV-EF1a-double floxed-hChR2(H134R)-EYFP-WPRE-HGHpA (AAV1)	Addgene; gift from Karl Deisseroth	20298-AAV1; RRID: Addgene_20298
Adeno-associated virus for Cre expression - pENN.AAV.hSyn.Cre.WPRE.hGH (AAV1)	Addgene; gift from James M. Wilson	105553-AAV1; RRID: Addgene_105553
Chemicals, peptides, and recombinant proteins
Human Aβ1-42	Abcam	Cat# ab82795
FM1-43	Thermo Fisher Scientific	Cat# T3163
ω-Agatoxin IVA	Alomone Labs	Cat# STA-500
Adenosine	Santa Cruz Biotechnology	Cat# sc-291838
LY341495	Tocris Bioscience	Cat# 1209
D-AP5 (APV)	Abcam	Cat# ab120003
TBOA	Tocris Bioscience	Cat# 1223
NMDA	Tocris Bioscience	Cat# 0114
Propidium iodide	Sigma-Aldrich	Cat# P4170
Experimental models: Organisms/strains
C57BL/6J mice	Oxford University Biomedical Services	RRID:IMSR_JAX:000664
Wistar rats	Charles River Laboratories UK	Strain code 003; RRID:RGD_737929
Software and algorithms
ImageJ	NIH	https://imagej.nih.gov/ij/; RRID: SCR_003070
WinWCP	Strathclyde University	https://spider.science.strath.ac.uk/sipbs/software_ses.htm; RRID: SCR_014713
Li-Cor Image Studio Lite	Li-Cor Biosciences	https://www.licor.com/bio/image-studio-lite/; RRID: SCR_013715
Prism	GraphPad	https://www.graphpad.com/scientific-software/prism/; RRID: SCR_002798