Table 1.
Molecules involved in neutrophil recruitment cascades in mice and humans
| Recruitment Cascades | Human or Mouse | Involved β2 Integrins | Involved Ligands | Involved Integrin Adaptor Proteins | Integrin Activation State Required | References |
|---|---|---|---|---|---|---|
| Slow-rolling | Mouse | LFA-1 | ICAM-1 | Talin-1 | ND | (16–19) |
| Human | LFA-1 | ICAM-1 | Talin-1 | E+ | (20) | |
| Arrest | Mouse | LFA-1 | ICAM-1 | Talin-1, kindlin-3 | ND | (16, 17, 21–23) |
| Human | LFA-1, Mac-1 | ICAM-1 | Talin-1, kindlin-3 | E+H+ | (7, 24) | |
| Spreading | Mouse | Mac-1 | ICAM-1, immune complex | Kindlin-3 | ND | (22, 25, 26) |
| Human | ND | ICAM-1 | Talin-1, kindlin-3 | E+H+ | (27, 28) | |
| Intravascular crawling | Mouse | Mac-1 | ICAM-1 | NA | ND | (29) |
| Trans-endothelial migration | Mouse | LFA-1, Mac-1 | JAM-A, JAM-C, ICAM-1 | NA | ND | (30–33) |
| Human | LFA-1 | JAM-A | NA | ND | (34) | |
| Migration /chemotaxis | Human | LFA-1, Mac-1 | ICAM-1, collagen, fibronectin, β-glucan | Talin-1, kindlin-3 | ND | (35–38) |
| Swarming | Mouse | LFA-1, Mac-1 | ND | Talin-1 | ND | (39) |
ICAM-1, intercellular adhesion molecule 1; JAM-A, junctional adhesion molecule-A; JAM-C, junctional adhesion molecule-C; LFA-1, lymphocyte function-associated antigen 1; Mac-1, macrophage-1 antigen; NA, not applicable; ND, not determined.