TABLE 1.
Course of pure red cell aplasia in six patients on antiretroviral therapy.
| Pt | Age (years) | At ART initiation |
At first presentation with anaemia |
Following discontinuation of FTC |
Follow-up and rechallenge |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hb | CD4 | CD4% | Hb | CD4 | CD4% | VL | Duration on FTC (months) | No. of units of PRC transfused | Hb at discontinuation of FTC post-last T/F | Further T/F | Time to recovery of Hb to >10 g/dL (months) | Time to rechallenge (months) | Duration of follow-up after rechallenge (months) | Hb at 6 months post-rechallenge | Hb at 12 months post-rechallenge | ||
| 1 | 61 | 8.8 | 329 | 19.3 | 2.7 | 345 | 22.7 | LDL | 8 | 7 | 10.7 | No | 2 | 16 | 24 | 12.0 | 12.4 |
| 2 | 48 | 7.2 | 203 | 16.2 | 1.8 | 312 | 25.9 | LDL | 5 | 12 | 6.5 | No | 2 | 4 | 12 | 10.9 | 11.7 |
| 3 | 55 | 12.2 | 326 | 12.9 | 3.2 | 389 | 28.71 | LDL | 4 | 12 | 6.5 | No | 2 | 10 | 7 | 13.3 | N/D |
| 4 | 35 | 8.2 | 83 | 7.44 | 2.7 | 213 | 9.35 | LDL | 5 | 53 | 8.4 | Yes | 1 | 16 | 36 | 12.7 | 13.3 |
| 5 | 37 | 9.4 | 237 | 30.4 | 2.6 | 255 | 23.4 | LDL | 2 | 15 | 7.4 | Yes | 4 | 14 | 18 | 12.9 | 12.6 |
| 6 | 23 | 9.2 | N/D | N/D | 1.8 | 261 | 8.09 | 504 | 4 | 18 | 8.4 | No | 1 | 10 | 13 | 13.2 | 13.0 |
Pt, patient; N/D, not done; PRC, packed red blood cells; T/F, transfusion; VL, viral load; FTC, emtricitabine; Hb, haemoglobin; ART, antiretroviral treatment; LDL, less than the level of detection.
Note: Hb = g/dL; CD4 cell count = cells/mm3.