Table 1.

Key questions for vitamin D prophylaxis in infancy

	Key question 1	Key question 2	Key question 3
Participants	Infants	Infants	Infants without risk factors Infants with risk factors
Intervention	Vitamin D supplement at any dose	Dose A of vitamin D	Vitamin D supplement until 12 months of age
Comparison	Placebo or no vitamin D supplement	Dose B of vitamin D	Vitamin D supplement until more than 12 months of age
Outcomes	Clinical outcomes: rickets (clinical or radiological signs), infections Anthropometric outcomes such as mineral bone density Levels of serum vitamin D (25OHD)
Adverse effects	Any adverse effect