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. 2021 Sep 8;12:102. doi: 10.1186/s40104-021-00618-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — CircCPE inhibited myoblasts apoptosis and differentiation in a miR-138 dependent manner. (A and B) The expression of apoptosis marker genes was detected by real-time qPCR and western blots after transfection with pCD2.1-NC + mimic NC, pCD2.1-NC + miR-138, pCD2.1- circCPE +miR-138 and pCD2.1-circCPE +mimic NC in bovine myoblasts. (C and D) The expression of differentiated marker genes was detected by real-time qPCR and western blots after after transfection with pCD2.1-NC + mimic NC, pCD2.1-NC + miR-138, pCD2.1- circCPE +miR-138 and pCD2.1-circCPE +mimic NC in bovine myoblasts. (E) Cell differentiation was detected by immunofluorescence (MyHC) after transfected with miR-138 mimics or co-transfected with circCPE or circCPE alone. The images were observed under a fluorescence microscope (scale bar indicates 1000 μm). Values are means ± SEM for three individuals. P < 0.05, P < 0.01