Fig. 1.

Experimental Design. Male C57BL/6 mice aged 6–8 weeks were randomized into 6 groups of 5 mice each. Animals were weighed and dosed with 10 mg/kg body weight Marimastat via oropharyngeal aspiration 1 h prior to dosing with dispersion media (DM; 0 µg), 10 µg, or 40 µg of MWCNT via oropharyngeal aspiration. Animals were euthanized 24-h post MWCNT exposure and tissues collected to assess pulmonary inflammation, serum peptide profile and serum bioactivity. (Figure generated in BioRender)