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. 2021 Sep 8;18:34. doi: 10.1186/s12989-021-00427-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Serum peptidomics heatmap. MWCNT-induced peptide serum profile changes assessed via Mass Spectrometry. MWCNT exposure increased total serum peptide composition in a differential dose-dependent manner. Left panel: Serum peptide changes resulting from MWCNT exposure. Blue box: Serum peptide composition induced exclusively by high dose (40 µg) MWCNT exposure; Red box: Serum peptide composition induced by exclusively low dose (10 µg) MWCNT exposure; Purple box: Serum peptide composition induced by both low and high dose MWCNT exposure. Right panel: Serum peptide profile generated by MWCNT and Marimastat exposure. MWCNT-induced serum peptide changes were abrogated by broad spectrum MMP inhibitor, Marimastat. These findings indicate an MMP-mediated mechanism of action for MWCNT in generating lung-derived serum bioactivity. N = 5 per group