Fig. 1.

Flow chart of TGSO. (All the subgraphs in this figure were created by the first author using the open source software Cytoscape in combination with existing experimental data, without any borrowing.) The initial PPI, combined with subcellular localization and gene expression data as well as network topology information, was integrated to obtain the comprehensive protein interaction network, and the network and protein conservative score were put into the iterative model to obtain the final required protein score