Algorithm: TGSO

Input: Original PPI network $G=(V,E)$, subcellular location data, orthologous and gene expression data, the parameters $\gamma$ and K

Output: Top K percent of proteins sorted by the vector P in descending order

Step1: Constructing the ADN according to the formula (1);

Step2: Constructing the CEN according to the formula (3);

Step3: Constructing the CLN according to the formula (6);

Step4: Constructing the PCIN according to the formula (8);

Step5: Obtaining the initial score vector $P_0$ according to the formula (11);

Step6: Let $t=0$; Obtaining P1according to formula (12);

Step7: Let $t=t+1$; Obtaining $P_{t+1}$ according to formula (12);

Step8: Repeating Step7 until $(||P_{t+1}-P_t||)/|E|<\gamma$;

Step9: Sort proteins by the value of P in the descending order;

Step10: Output top K percent of sorted proteins.