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. 2021 Sep 8;19:274. doi: 10.1186/s12951-021-01022-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CD73+hucMSC-EVs ameliorate SCI and decrease intracellular cAMP levels in mice. (A and B) In vivo biodistribution of DiR-labeled CD73+hucMSC-EVs. Mice are analyzed at 24 h after A subcutaneous injection of EVs around injured spinal cord and B intraperitoneal injection of EVs. C BMS scores at different time-point after spinal cord injury. D BBB scores at different time-point after spinal cord injury. E cAMP levels from cerebrospinal fluid at different time-point after spinal cord injury. F Histological images (H&E staing), G Nissl staining and (H) TUNEL staining of longitudinal sections of injured spinal cords on day 21