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. 2021 Sep 8;19:274. doi: 10.1186/s12951-021-01022-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — CD73+hucMSC-EVs regulate M1/M2 polarization of microglia in mice. A and B Changes of arginase-1 and iNOS are determined by immunofluorescence in different groups at × 5 magnification. C Fluorescent intensities are normalized to the sham group. (*p < 0.05 versus SCI group, #p < 0.05 versus SCI + CD73+hucMSC-EVs group, n = 5). D and E Representative dot spot of flow cytometry for microglia/macrophage subsets is shown. CD206 and CD86 are selected as biomarkers of M2 and M1 microglia, respectively. The data are calculated as M2:M1. (*p < 0.05 versus SCI group, #p < 0.05 versus SCI + CD73+hucMSC-EVs group, n = 5)