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. 2021 Sep 7;18:81. doi: 10.1186/s12986-021-00601-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The effects of SZP on the parameters of renal function and kidney tissue in DN mice. The expression level of 24-h urinary protein (a). The expression level of serum BUN (b). The expression level of Cr (c). The Photomicrographs (HE, magnification × 400; PAS, magnification × 400; Masson's trichrome-stained, magnification × 400) of different groups (d). Black arrows indicated glomerular hypertrophy, mesangial expansion,tubular dilatation and collagen fiber deposition.The values presented are the means ± SD of six independent experiments (n = 6) and differences between mean values were assessed by ANOVA. ###P < 0.01 versus sham control group, ***P < 0.01 versus DN group. Cr, serum creatinine. HE, hematoxylin and eosin; PAS, periodic acid-Schiff