Fig. 5.

The effects of SZP on the secretion of inflammatory cytokines and proteins in HG-treated HK-2 cells. The cell viability of HK-2 cells after SZP treatment (a). The expression level of TNF-α (b). The expression level of MCP-1 (c). The expression level of IL-6 (d). NF-κB protein expressions in HG-stimulate HK-2 cells after SZP treatment (e). The values presented are the means ± SD of three independent experiments (n = 3) and differences between mean values were assessed by ANOVA. ###P < 0.001 versus sham control group, ***P < 0.001 versus HG group. HG, high-glucose; TNF-α, Tumor necrosis factor-α; MCP-1, Monocyte chemotactic protein-1; IL-6, Interleukin 6. NF-κB, Nuclear factor-kappa B