Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 28;12(20):6242–6253. doi: 10.7150/jca.58004

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

NEDD4L overexpression degrades the protein kinases. (A) Overlap of genes showing those both with predicted the ubiquitination substrates and confirmed interacting molecules of NEDD4L. (B) Biological network enrichment of 28 intersection genes predicted by STRING analysis. (C) Representative western blot analysis of NEDD4L overexpressed (NEDD4L), down-regulated (si-NEDD4L) or control cells. The levels of NEDD4L, phospho (p)-MEK, MEK, p-ERK and ERK, ERBB3 and β-actin (ACTIN) in ACHN cells were measured. The result is representative of three separate experiments. (D) NEDD4L overexpressed or control cells were plated overnight and subsequently treated with EBSS for 6 h and resolved in an SDS-PAGE gel. Samples were immunoblotted against NEDD4L, LC3, p62, ULK1 and ACTIN. (E) Protein-protein interactions network of 28 intersection genes predicted by Pathway Common.