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. 2021 Aug 26;12(20):6170–6181. doi: 10.7150/jca.56419

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High NNMT in stromal cells promotes migration by 1-MNA. (A, B) The migration was significantly decreased in CCD-18Co cells after downregulation of NNMT for 48 h by wound healing assay. (C) The 1-MNA level in medium with CCD-18Co cell culture was increased, whereas the intracellular 1-MNA of CCD-18Co was decreased after downregulation of NNMT. (D) The intracellular 1-MNA level of SW480 cells was increased after overexpression of NNMT, whereas the intracellular 1-MNA of HT-29 cells was decreased after downregulation of NNMT.