Table 1.
Association between YTHDF2 rs3738067 A>G polymorphism and Wilms tumor risk
| Genotype | Cases (N=441) | Controls (N=1316) | P a | Crude OR (95% CI) | P | Adjusted OR (95% CI) b | P b |
|---|---|---|---|---|---|---|---|
| rs3738067 (HWE=0.860) | |||||||
| AA | 253 (57.37) | 731 (55.55) | 1.00 | 1.00 | |||
| AG | 158 (35.83) | 498 (37.84) | 0.92 (0.73-1.15) | 0.457 | 0.91 (0.73-1.15) | 0.444 | |
| GG | 30 (6.80) | 87 (6.61) | 1.00 (0.64-1.55) | 0.987 | 1.00 (0.64-1.54) | 0.981 | |
| Additive | 0.632 | 0.96 (0.80-1.14) | 0.632 | 0.96 (0.80-1.14) | 0.619 | ||
| Dominant | 188 (42.63) | 585 (44.45) | 0.505 | 0.93 (0.75-1.15) | 0.505 | 0.93 (0.75-1.15) | 0.491 |
| Recessive | 411 (93.20) | 1229 (93.39) | 0.889 | 1.03 (0.67-1.59) | 0.888 | 1.03 (0.67-1.58) | 0.892 |
HWE, Hardy-Weinberg equilibrium; OR, odds ratio; CI, confidence interval.
a χ2 test for genotype distributions between Wilms tumor patients and cancer-free controls.
b Adjusted for age and gender.