Table II.

The effects of vildagliptin on metabolic parameters in DM rats after treatment for 12 weeks

Parameter	Groups
	CON	DM	Lvil	Hvil
Body weight [g]	554.96 ±20.36	479.04 ±10.24**	508.97 ±14.61**##	496.26 ±21.49**
Fasting blood glucose [mmol/l]	5.14 ±0.36	21.04 ±2.15**	14.27 ±1.36**##	16.88 ±1.78**##
AUCgluose [mmol/l/h]	15.92 ±1.78	53.25 ±2.22**	39.96 ±3.50**##	42.03 ±5.59**##
Insulin [mIU/l]	38.89 ±1.97	54.7384 ±6.39**	37.15 ±6.09##	36.98 ±7.06##
HOMA index	8.87 ±0.62	50.95 ±5.61**	23.37 ±3.35**##	27.88 ±6.47**##
TC [mmol/l]	1.39 ±0.05	2.40 ±0.36**	1.66 ±0.27*##	1.55 ±0.21##
TG [mmol/l]	0.60 ±0.14	1.44 ±0.30**	1.48 ±0.32**	1.31 ±0.28**
HDL-C [mmol/l]	0.59 ±0.08	0.42 ±0.08**	0.59 ±0.10##	0.50 ±0.08
LDL-C [mmol/l]	0.2 ±0.07	0.53 ±0.10**	0.25 ±0.05##	0.22 ±0.05##

CON – control, DM – diabetes mellitus, Lvil – low dose of vildagliptin, Hvil – high dose of vildagliptin.

^*P < 0.05

^**p < 0.01 vs. normal control group;

^##p < 0.01 vs. diabetes group.