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. 2019 May 15;17(5):1388–1399. doi: 10.5114/aoms.2019.85202

Figure 2.

Figure 2

Activation of anterior cingulate cortex (ACC) excitatory projections in the dorsomedial striatum (DMS) reduces the pain threshold in normal mice. A – Injection and implantation locations. B – The ACC neurons projecting downstream to the DMS (100×). Scale bars = 100 μm. C, D – are the mechanical pain and thermal pain threshold tests when blue light stimulated the DMS of the normal mice (n = 10 or 12; *p < 0.05, **p < 0.01, ***p < 0.001). E, F – show the mechanical pain threshold test and thermal pain threshold test for normal mice when the yellow light was applied to the DMS (n = 9; p > 0.05)