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. 2019 May 15;17(5):1388–1399. doi: 10.5114/aoms.2019.85202

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Copyright: © 2019 Termedia & Banach

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

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Inhibition of the anterior cingulate cortex (ACC) projections to the dorsomedial striatum (DMS) relieves pain in CCI mice. A, B – show the mechanical pain and thermal pain threshold test results for CCI mice during blue light stimulation of the DMS region between the ChR2-off-right group and the ChR2-on-right group (n = 8 or 10, p > 0.05). C, D – show the mechanical pain thresholds and thermal pain thresholds for CCI mice during yellow light inhibition of the DMS on day 3 and day 7 in the NpHR-off group and NpHR-on group (n = 8 or 9, *p < 0.05, **p < 0.01, ***p < 0.001).

*NpHR-on-right groups versus NpHR-off-right group; ^#NpHR-on-right group versus NpHR-on-left group.