Therapy with csDMARDs should be started as soon as the diagnosis of RA is made |
Treatment not initiated at diagnosis |
15 |
Lag time in treatment initiation from diagnosis (> 3 months) |
29 |
Treatment should be aimed at reaching a target of sustained remission or low disease activity in every patient |
Never achieving remission |
64 |
Time to first-ever remission (> 6 months) |
54 |
Sustained remission (> 12 months) |
19 |
Monitoring should be frequent in active disease (every 1–3 months); if there is no improvement by at most 3 months after the start of treatment or the target has not been reached by 6 months, therapy should be adjusted |
Interval of disease activity monitoring (> 3 months) |
33 |
MTX should be part of the first treatment strategy |
Lack of MTX use in monotherapy or in combination with GC and/or other csDMARDs |
10–12 |
Short-term glucocorticoids should be considered when initiating or changing csDMARDs, in different dose regimens and routes of administration, but should be tapered as rapidly as clinically feasible |
GC treatment time (> 6 months) |
25 |
If the treatment target is not achieved with the first csDMARD strategy, when poor prognostic factors are present, addition of a bDMARD or a tsDMARD should be considered; current practice would be to start a bDMARD |
No bDMARD treatment planned (despite active disease after ≥ 2 treatment schemes/drugs) |
34 |
Referred for bDMARD treatment (active disease only after ≥ 3 treatment schemes/drugs) |
51 |