3. Table of study characteristics/outcomes: quality of life.
| Author | Outcome domain | Outcome measure | Time points in months (time frame) | Data reported | Pooled |
| Aboumatar 2019 | Health‐related QoL | SGRQ | 4 (ST) | mean change, 95% CI, N/group | Yes |
| Aiken 2006 | Generic QoL | SF‐36 | 3 (ST); 6 (ST); 9 (MT); 12 (MT) | slopes of trajectories | No |
| Bendstrup 1997 | Health‐related QoL | CRQ, YGLQ | 1 (ST); 3 (ST) | mean change, SEM/group/P value | Yes |
| Bernocchi 2017 | Health‐related QoL | CAT score, Barthel score | 4 (ST); 6 (ST) | mean change, SD, N/group | No |
| Bourbeau 2003 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 6 (ST); 9 (MT) | mean, 95% CI, N/group | Yes |
| Boxall 2005 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 3 (ST); 12 (MT) | mean change, mean at follow‐up with SD, N/group/time point mean difference, 95% CI, P value | Yes |
| Cambach 1997 | Health‐related QoL | CRDQ (CRQ ‐ recalculated) | 3 (ST); 6 (MT) | mean at baseline, mean change, SD, N/group | No |
| Dheda 2004 | Health‐related QoL | SGRQ ‐ total | 12 (MT) | mean change, SE. N/group, P value | Yes |
| Engstrom 1999 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 12 (MT) | mean, SE, N/group/time point | Yes |
| Fan 2012 | Health‐related QoL; generic QoL | SGRQ ‐ total, SGRQ ‐ subtotals; SF‐12 MCS; SF‐12 PCS | 12 (MT) | mean change, SD, N/group | Yes |
| Farrero 2001 | Health‐related QoL | CRQ | 3 (ST); 12 (MT) | not reported | No |
| Fernandez 2009 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 12 (MT) | mean, SD, N/group/time point | Yes |
| Freund 2016 | n.a. | n.a. | n.a. | n.a. | n.a. |
| Gottlieb 2011 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 6 (ST); 12 (MT); 18 (LT) | mean, SD, N/group/time point | Yes |
| Güell 2000 | Health‐related QoL; generic QoL | CRQ, BODE Index, VAS | 3 (ST); 6 (ST); 9 (MT); 12 (MT); 18 (LT); 24 (LT) | mean, SE/group/time point | Yes |
| Güell 2006 | Health‐related QoL | CRQ | 4 (ST) | mean, SD, N/group/time point | Yes |
| Haesum 2012 | n.a. | n.a. | n.a. | n.a. | n.a. |
| Jimenez‐Reguera 2020 | Health‐related QoL; generic QoL | SGRQ, CAT, EQ‐5D, VAS | 6 (ST); 12 (MT) | mean, SD, N/group/time point | Yes |
| Kalter‐Leibovici 2018 | Health‐related QoL; generic QoL | SGRQ‐total, SF‐12 MCS, SF‐12 PCS | 12 (MT); 24 (LT) | mean change, SD, N/group | Yes |
| Kennedy 2013 | Generic QoL | EQ‐5D | 6 (ST); 12 (MT) | mean change, SD, N/group | No |
| Kessler 2018 | Health‐related QoL | SGRQ ‐ COPD specific, BODE Index | 12 (MT) | mean, SD, N/group (at 12 months) adjusted MD, 95% CI, N, P value | No |
| Khan 2019 | Health‐related QoL | BODE Index | 6 (ST) | MD, 95% CI, P value, N | No |
| Ko 2016 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 12 hs (MT) | mean change, SD, N/group | Yes |
| Koff 2009 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 3 (ST) | mean change, 95% CI, N/group | Yes |
| Kruis 2014 | Health‐related QoL; generic QoL | SGRQ ‐ total, SGRQ ‐ subscores, CCQ, SF‐36 PCS, SF‐36 MCS | 12 (MT) | mean change, 95% CI, N/group | Yes |
| Lenferink 2019 | Health‐related QoL | CRQ, CAT | 6 (ST); 12 (MT) | mean change, SD, N/group (additional data) | Yes |
| Lilholt 2017 | Generic QoL | SF‐36 MCS, SF‐36 PCS | 12 (MT) | MD, 95% CI, P value, N | Yes |
| Littlejohns 1991 | n.a. | n.a. | n.a. | n.a. | n.a |
| Lou 2015 | Health‐related QoL | BODE Index | 48 (LT) | mean change, SD, N/group adjusted median D, 95% CI, P value | No |
| Mendes 2010 | Health‐related QoL | BODE Index | 3 (ST) | mean, SD, N/group/time point ‐ box and whisker plots | No |
| Öztürk 2020 | Health‐related QoL; generic QoL | SGRQ, CAT, SF‐36 subdomains | 3 (ST) | mean, SD, N/group/time point | Yes |
| Rea 2004 | Health‐related QoL; generic QoL | CRQ, SF‐36 subdomains | 12 (MT) | mean, N/group/time point, P value difference | Yes |
| Rice 2010 | Health‐related QoL | SGRQ ‐ total | 12 (MT) | mean change/group mean difference (95% CI) | Yes |
| Rose 2017 | Health‐related QoL | SGRQ ‐ total, BODE Index | 6 (ST); 12 (MT) | mean, SD/group | Yes |
| Sanchez‐Nieto 2016 | n.a. | n.a. | n.a. | n.a. | n.a |
| Silver 2017 | n.a. | n.a. | n.a. | n.a. | n.a |
| Smith 1999 | Health‐related QoL | COOP | 12 (MT) | mean, SE, N/group/follow‐up | No |
| Sridhar 2008 | Health‐related QoL | CRQ | 24 (LT) | mean, SD, N/group/time point | Yes |
| Strijbos 1996 | n.a. | n.a. | n.a. | n.a. | n.a |
| Tabak 2014 | Health‐related QoL; generic QoL | CCQ, EQ‐5D Index, EQ‐5D VAS score | 1 (ST); 3 (MT) | mean, SD, N/group/time point | No |
| Theander 2009 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 3 (ST) | mean baseline, SD mean, SD/group | Yes |
| Titova 2017 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 6 (ST); 12 (MT); 4 (LT) | mean, 95% CI/group/time point MD, 95% CI, N, P value | Yes |
| Trappenburg 2011 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals, CCQ | 6 (ST) | mean change, SE, N/group | Yes |
| van Wetering 2010 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 4 (ST); 12 (MT); 24 (LT) | mean, SE, N/group MD, MD adjusted, SE, P value | Yes |
| Vasilopoulou 2017 | Health‐related QoL | SGRQ ‐ total, CAT score | 2 (ST); 14 (MT) | mean, SD, N/group/time point | Yes |
| Vianello 2016 | Generic QoL | SF‐36 PCS, SF‐36 MCS | 12 (MT) | mean, SD, N/group | Yes |
| Wakabayashi 2011 | Health‐related QoL | SGRQ ‐ total | 6 (ST); 12 (MT) | mean, SD, N/group/time point | Yes |
| Wang 2017 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 1 (ST); 3 (ST); 6 (ST); 12 (MT) | mean, SD, N/group/time point | Yes |
| Wijkstra 1994 | Health‐related QoL | CRQ | 3 (ST); 6 (ST); 12 (MT); 18 (LT) | mean change, SD, N/group | Yes |
| Wood‐Baker 2006 | Health‐related QoL | SGRQ ‐ total, SGRQ ‐ subtotals | 6 (ST); 12 (MT) | mean, SD, N/group/time point | Yes |
| Zhang 2020 | Health‐related QoL | CAT score | 3 (ST); 6 (ST); 12 (MT); 24 (LT) | mean, SD, N/group/time point | No |
| Zwar 2016 | Health‐related QoL | SGRQ ‐ total, CAT score | 12 (MT) | mean, SD, N, P value, t test statistic/group/time point | Yes |
Abbreviations. CAT: COPD Assessment Test; CCQ: Chronic COPD Questionnaire; CI: confidence interval; COOP: Dartmouth Primary Care Co‐operative Quality of Life Questionnaire; CRQ: Chronic Respiratory Questionnaire; EQ‐5D: EuroQol Quality of Life ‐ 5 domains; LT: long‐term follow‐up; MCS: Mental Component Score; MD: mean difference; MT: medium‐term follow‐up; QoL: quality of life; PCS: Physical Component Score; SD: standard deviation; SE: standard error; SGRQ: St. George's Respiratory Questionnaire; SF‐12: Short Form‐12; SF‐36: Short Form‐36; SIP: Sickness Impact Profile; ST: short‐term follow‐up; VAS: visual analogue scale; YGLQ: York Quality of Life Questionnaire.