6. Table of study characteristics outcomes: secondary outcomes.
| Author | Outcome domain | Outcome measure | Time points, months (time frame) | Data reported | Pooled |
| Aboumatar 2019 | Mortality | Mortality | 4 (ST) | n, N | Yes |
| Bernocchi 2017 | Dyspnoea | mMRC | 4 (ST) | mean change, SD, N/group | Yes |
| Mortality | Mortality | 4 (MT) | n, N | Yes | |
| Bourbeau 2003 | Lung function | FEV₁, FEV₁% predicted | 12 (MT) | mean, SD, N/group/time point | Yes |
| Boxall 2005 | Dyspnoea | Borg score | 3 (ST); 12 (MT) | mean change, mean at follow‐up with SD, N/group/time point mean difference, 95% CI, P value | Yes |
| Engstrom 1999 | Depression | MACL | 12 (MT) | mean, SE, N/group/time point | No |
| Fan 2012 | Mortality | Mortality | 12 (MT) ‐ mean 250 days' follow‐up | n, N | Yes |
| Farrero 2001 | Lung function | FEV₁% predicted | 12 (MT) | mean, SD, N/group/time point, P value | Yes |
| Mortality | Mortality | 12 (MT) | n, N | Yes | |
| Fernandez 2009 | Lung function | FEV₁% predicted | 12 (MT) | mean, SD, N/group/time point | Yes |
| Gottlieb 2011 | Dyspnoea | Borg score | 6 (ST); 12 (MT); 18 (LT) | mean, SD, N/group/time point | Yes |
| Güell 2000 | Lung function | FEV₁% predicted | 3 (ST); 6 (ST); 9 (MT); 12 (MT); 18 (LT); 24 (LT) | mean, SE, group/time point | Yes |
| Borg score | 3 (ST); 6 (ST); 9 (MT); 12 (MT); 18 (LT); 24 (LT) | mean, SE, group/time point | Yes | ||
| Güell 2006 | Depression | Revised Symptom Checklist (SCL‐90‐R) | 4 (ST) | mean, SD, N/group/time point | No |
| Jimenez‐Reguera 2020 | Lung function | FEV₁% predicted (reported as FEV₁ in litres) | 6 (ST) | mean, SD, N/group/time point | Yes |
| Kalter‐Leibovici 2018 | Lung function | FEV₁% predicted | 12 (MT); 24 (LT) | mean change, SD, N/group | Yes |
| Dyspnoea | mMRC | 12 (MT); 24 (LT) | mean change, SD, N/group | Yes | |
| Kessler 2018 | Depression | HADS depression, HADS anxiety | 12 (MT) | mean, SD, N/group (at 12 months) adjusted MD, 95% CI, N, P value | Yes |
| Mortality | Mortality | 12 (MT) | n, N | Yes | |
| Khan 2019 | Lung function | FEV₁% predicted | 6 (ST) | mean change, SD, N/group, MD, 95% CI | Yes |
| Dyspnoea | mMRC | 6 (ST) | mean change, SD, N/group, MD, 95% CI | Yes | |
| Ko 2016 | Lung function | FEV₁% predicted | 12 (MT) | mean change, SD, N/group | Yes |
| Dyspnoea | mMRC | 12 (MT) | mean change, SD, N/group | Yes | |
| Koff 2009 | 3 (ST) | mean change, 95% CI, N/group | Yes | ||
| Kruis 2014 | Dyspnoea | mMRC | 12 (MT) | mean change, 95% CI, N/group | Yes |
| Mortality | Mortality | 12 (MT) | n, N | Yes | |
| Lenferink 2019 | Lung function | FEV₁% predicted | 12 (MT) | mean change, SD, N/group (additional data) | Yes |
| Dyspnoea | mMRC | 6 (ST); 12 (MT) | mean change, SD, N/group (additional data) | Yes | |
| Depression | HADS total score | 6 (ST); 12 (MT) | mean change, SD, N/group | Yes | |
| Littlejohns 1991 | Lung function | FEV₁% predicted | 12 (MT) | mean change, 95% CI, N/group | Yes |
| Depression | HADS depression, HADS anxiety | 12 (MT) | mean change, 95% CI, N/group | Yes | |
| Mortality | Mortality | 12 (MT) | n, N | Yes | |
| Lou 2015 | Lung function | FEV₁% predicted | 48 (LT) | mean change, SD, N/group adjusted median D, 95% CI, P value | No |
| Dyspnoea | mMRC | 48 (LT) | mean change, SD, N/group adjusted median D, 95% CI, P value | Yes | |
| Mortality | Mortality | 48 (MT) | n, N | Yes | |
| Mendes 2010 | Dyspnoea | mMRC | 3 (ST) | mean, SD, N/group/time point ‐ box and whisker plots | No |
| Öztürk 2020 | Lung function | FEV₁ | 3 (ST) | mean, SD, N/group/time | Yes |
| Dyspnoea | mMRC | 3 (ST) | mean, SD, N/group/time | Yes | |
| Depression | HADS depression, HADS anxiety | 3 (ST) | mean, SD, N/group/time | Yes | |
| Rice 2010 | Mortality | Mortality | 12 (MT) | n, N | Yes |
| Rose 2017 | Depression | HADS depression, HADS anxiety | 6 (ST); 12 (MT) | mean, SD/group | Yes |
| Mortality | Mortality | 12 (MT) | n, N | Yes | |
| Sanchez‐Nieto 2016 | Mortality | Mortality | 12 (MT) | n, N | Yes |
| Smith 1999 | Lung function | FEV₁, FEV₁% predicted | 12 (MT) | mean, SE/group | No |
| Mortality | Mortality | 12 (MT) | n, N | Yes | |
| Sridhar 2008 | Lung function | FEV₁, FEV₁% predicted | 48 (LT) | mean, SD, N/group/time point | Yes |
| Mortality | Mortality | 48 (MT) | n, N | Yes | |
| Titova 2017 | Depression | HADS depression, HADS anxiety | 6 (ST); 12 (MT); 24 (LT) | mean, 95% CI/group/time point MD, 95% CI, N, P value | Yes |
| Mortality | Mortality | 24 (MT) | n, N | Yes | |
| Trappenburg 2011 | Depression | HADS depression, HADS anxiety | 6 (ST) | mean change, SE, N/group | Yes |
| van Wetering 2010 | Lung function | FEV₁% predicted | 4 (ST) | mean, SE, N/group | Yes |
| Dyspnoea | MRC | 4 (ST); 12 (MT); 24 (LT) | mean, SE, N/group | Yes | |
| Vasilopoulou 2017 | Dyspnoea | mMRC | 2 (ST); 14 (MT) | mean, SD, N/group/time point | Yes |
| Vianello 2016 | Depression | HADS depression, HADS anxiety | 12 (MT) | mean, SD, N/group | Yes |
| Mortality | Mortality | 12 (MT) | n, N | Yes | |
| Wakabayashi 2011 | Lung function | FEV₁% predicted | 6 (ST); 12 (MT) | mean, SD, N/group/time point | Yes |
| Dyspnoea | mMRC | 6 (ST); 12 (MT) | mean, SD, N/group/time point | Yes | |
| Wang 2017 | Lung function | FEV₁ | 3 (ST); 6 (ST); 12 (MT) | mean, SD, N/group/time point | No (reporting error) |
| Dyspnoea | mMRC | 3 (ST); 6 (ST); 12 (MT) | mean, SD, N / group / time point | No (reporting error) | |
| Wijkstra 1994 | Lung function | FEV₁ | 3 (ST); 6 (ST); 12 (MT); 18 (LT) | mean change, SD, N/group (only for 3 months' follow‐up) | Yes |
| Wood‐Baker 2006 | Lung function | FEV₁, FEV₁% predicted | 6 (ST); 12 (MT) | mean, SD, N/group | Yes |
| Zhang 2020 | Lung function | FEV₁, FEV₁% predicted | 3 (ST); 6 (ST); 12 (MT); 24 (LT) | mean, SD, N/group/time point | Yes |
| Dyspnoea | mMRC | 3 (ST); 6 (ST); 12 (MT); 24 (LT) | mean, SD, N/group/time point | ||
| Zwar 2016 | Lung function | FEV₁% predicted | 12 (MT) | mean, SD, N/group/time point MD, 95% CI, P value, N | Yes |
Abbreviations. CI: confidence interval; FEV₁: forced expiratory volume in one second; HADS: Hospital Anxiety and Depression Scale; LT: long‐term follow‐up; MD: mean difference; mMRC: modified Medical Research Council Dyspnoea Scale; MT: medium‐term follow‐up; SD: standard deviation; SE: standard error; ST: short‐term follow‐up.