Güell 2006.

Study characteristics
Methods	RCT; follow‐up: 4 months; control group: usual care
Participants	Randomised: 40, I: 20, C: 29 Completed: 35, I: 18, C: 17 Mean age: I: 68 years, C: 66 years Male: I: 88%, C: 100% Inclusion criteria: age ≤ 75 years, FEV₁ < 70%, FEV₁/FVC < 65%, PaO₂ > 55 mmHg at rest with no indication for prescribing home oxygen therapy Exclusion criteria: psychiatric disturbance; no heart, bone, or joint disease; exacerbation or hospitalisation in previous 2 months
Interventions	Pulminary rehabilitation programme of 4 months, including ‐ First 2 months: two 30‐minute sessions each week, including relaxation techniques, breathing retraining, and chest wall and abdominal muscle wall work. Patients attended four 45‐ to 60‐minute educational sessions ‐ Month 2 to 4: five 30‐minute sessions weekly exercise training on cycle ergometer Intervention duration: 4 months Disciplines involved: nurse, physiotherapist, pulmonologist
Outcomes	MBHI, Revised Symptom Checklist (SCL‐90‐R), 6MWD, CRQ
Notes	Dominant component: exercise
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "randomization was done at inclusion of consecutive patients" Comment: it is not clear how the sequence was generated
Allocation concealment (selection bias)	High risk	Quote: "randomization was not concealed"
Blinding of participants and personnel (performance bias) All outcomes	High risk	Quote: "neither patients nor clinicians were blinded to allocation"
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "the technicians who collected the data were blinded to patient allocation, as were the data analysts, until the analysis was deemed complete"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: l oss to follow‐up comparable between groups (2 vs 3)
Selective reporting (reporting bias)	Low risk	Comment: a ll outcomes reported