Theander 2009.

Study characteristics
Methods	RCT; 3 months; control group: usual care
Participants	Eligible: 30 Randomised: 30, I: 15, C: 15 Completed: 26, I: 12, C: 14 Mean age: I: 66 years, C: 64 years Sex (% male): I: 25, C: 71 Inclusion criteria: diagnosis of COPD according to British guidelines, with FEV₁ between 60% and 25% post bronchodilation, age ≤ 75 years Major exclusions: disabling or severe disease other than COPD, impaired pulmonary function due to other disease, long‐term oxygen therapy, alpha₁‐antitrypsin deficiency, cancer disease, untreated obstructive sleep apnoea syndrome, no COPD‐related symptoms affecting activities of daily life
Interventions	Multi‐disciplinary programme ‐ Physiotherapy 2 days per week (1 hour) for 12 weeks, with additional home training after 1 month ‐ Dietician support (3 sessions of 1 hour): education and, if needed, additional nutritional supplementation ‐ Occupational therapist: education and teaching ‐ Nurse (2 sessions of 1 hour): education and self‐care advice Intervention duration: 3 months Disciplines involved: physiotherapist, dietician, occupational therapist, nurse
Outcomes	BMI, FEV₁, fatigue impact scale, 6MWD, grip strength, SGRQ, SF‐36
Notes	Dominant component: exercise
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "for the randomisation we prepared 80 sealed opaque envelopes with assignment information: 40 for the rehabilitation group and 40 for the control group"
Allocation concealment (selection bias)	Low risk	Quote: "randomization procedures were performed by an independent person from the research group, who took a random envelope from the prepared box with sealed envelopes"
Blinding of participants and personnel (performance bias) All outcomes	High risk	Comment: p articipants and treating therapists not likely to have been blinded to group allocation
Blinding of outcome assessment (detection bias) All outcomes	High risk	Quote: "the data collection was performed by members of the rehabilitation group. The data collection was not blinded to the data collector"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: c omparable dropout rates
Selective reporting (reporting bias)	Low risk	Comment: study protocol is not available, but it is clear that published reports include all expected outcomes, including those that were pre‐specified