Figure 1.

A. Composite lesion scores of heart, lungs, liver and kidney from 4 age groups of C57BL/6 and C57BL/6 x BALB/c (CB6F1) male mice show differences in the two strains at the same chronological age points. N=12/cohort. B. Drug response was determined by a significant decrease (P≤0.05) in lesion scores designated by an “X”, compared to non-medicated lesion scores over the course of 3 months in male and female C57BL/6 mice starting at 20 months of age. *For males, as females only showed drug response in the kidney. All mice were obtained from the National Institute on Aging aged rodent colony