Table 1.

Summary information on PGIs and disease–gene associations curated from different data sources

Database	Gene/protein	Disease	Node	Interaction	Selection/filter
HuRIa	8327	–	8327	19 082	HuRI
GTRDb	8275	–	8275	52 569	Promotor (−1000, +1000); more than 8 binding sites per gene
Reactome	5219	–	5219	29 328	–
String	13 444	–	13 444	91 019	Experimentally confirmed with score ≥350
DisGeNET	7635	8431	16 066	67 993	DGA score ≥0.3
Mimminer	–	2646	2646	9840	Similarity score >0.6
Gene network	18 718	–	18 718	183 457	–
Disease–gene network	19 463	10 103	29 566	261 298	–

^aHuRI—Human Reference Interatome

^bGTRD—Gene Transcription Regulation Database