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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Curr Opin Physiol. 2021 Aug 17;23:100472. doi: 10.1016/j.cophys.2021.100472

Figure 1. Influence of gut microbiome on cellular transformation and metastasis.

Figure 1.

In a prototypic example, certain components of a Western diet can influence gut microbiota and generation of metabolites through altered metabolism and an exaggerated immune response. A combination of these changes may lead to cellular transformation and neoplasia. The onset of a malignant disease can be further influenced by disruption of gut vascular barrier leading to metastatic spread. The gut microbiome has also been recently shown to promote switching of mutant p53 (mp53) from tumor-suppressive into an oncogenic protein to confer a malignant phenotype throughout the gut.