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. 2021 Aug 25;8:699827. doi: 10.3389/fmolb.2021.699827

FIGURE 2.

FIGURE 2

Application of exogenous Ang II increased APs transiently, and the effect could be attenuated by the AT1R blocker but not the AT2R blocker. (A) Ang II increased the APs of mESC-CMs in a transient manner. Raw traces of spontaneous APs at the basal level and upon treatment with 10–7 M Ang II in mESC-CMs (left panel). Summarized data on the AP rate and the DD slope of APs (right panel). (B) AT1R blocker attenuated Ang II–induced changes in APs. Raw traces of spontaneous APs at the basal level and upon treatment with 50 μM losartan, followed by the subsequent application of 10–7 M Ang II in mESC-CMs (left panel). Summarized data on the AP rate and the DD slope of APs at the basal level or upon treatment with 50 μM losartan, followed by 10–7 M Ang II (right panel). Losartan attenuated Ang II–induced changes in the parameters of APs. (C) AT2R blocker did not affect Ang II–induced changes in APs. Raw traces of spontaneous APs at the basal level and upon treatment with 10 μM PD123319, followed by the subsequent application of 10–7 M Ang II in mESC-CMs (left panel). Summarized data on the AP rate and the DD slope of APs at the basal level or upon treatment with 10 μM PD123319, followed by 10–7 M Ang II (right panel). PD123319 did not affect Ang II–induced changes in the parameters of APs. Values are mean ± SEM of 4–6 independent experiments. *p < 0.05 vs. control group.