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. 2021 Aug 25;8:700630. doi: 10.3389/fcvm.2021.700630

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Copyright © 2021 Hua, Zhou, Hou, Chen, Wang, Zhang, Zhou, He and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SBP suppressed the proliferation and migration stimulated by ox-LDL. (A) Cell proliferation was tested using CCK-8 cell proliferation assays. The proliferation of HCASMC was activated by ox-LDL, and SBP reversed the effect of ox-LDL in cell multiplication. (B) The cell viability among groups at 0, 24, and 48 h was exhibited in histogram B. (C) Cell cycle assay is presented. (D) Plotted cell cycle statistical analysis, suggesting that SBP relieved the stimulation of ox-LDL in HCASMCs. (E) Cells that migrated to the lower side of the filter membrane. (F) Number of migrated cells in the Transwell assay is calculated. *p < 0.05, **p < 0.01, ***p < 0.001.