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. 2021 Aug 25;13:686506. doi: 10.3389/fnagi.2021.686506

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Copyright © 2021 Peng, Fang, Xu, Liu, Qian, Gong, Zhao, Ma, Xia and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isoflurane inhalation selectively impairs contextual fear memory and this effect is exacerbated in diabetic mice. (A) Freezing (% time) in response to the foot-shock context (chamber) among adult WT mice and T2DM mice (DM groups) exposed to 1.3% isoflurane inhalation for 6 h (Anes and DM + Anes groups) or control inhalation (100% O₂ for 6 h). (B) Freezing time during exposure to the conditioned sound cue in a different context. Data are expressed as mean ± SD of 7–8 mice for each treated group and analyzed with one-way ANOVA test followed by Bonferroni multiple comparison test. ^∗P < 0.05 and ^∗∗P < 0.01 vs. Con group; ^&P < 0.05 vs. Anes group; ^#P < 0.05 vs. DM group.