Database/search platform/date of last search	Search strategy	Results (number of hits)
Airways Register (via Cochrane Register of Studies) Date of most recent search: 1 May 2020	1 MeSH DESCRIPTOR Pulmonary Disease, Chronic Obstructive Explode All AND INREGISTER 2 MeSH DESCRIPTOR Bronchitis, Chronic AND INREGISTER 3 ((obstruct*) near3 (pulmonary or lung* or airway* or airflow* or bronch* or respirat*)):ti,ab AND INREGISTER 4 COPD:MISC1 AND INREGISTER 5 (COPD OR COAD OR COBD OR AECOPD):TI,AB AND INREGISTER 6 #1 OR #2 OR #3 OR #4 OR #5 AND INREGISTER 7 MeSH DESCRIPTOR Patient Compliance Explode All AND INREGISTER 8 MeSH DESCRIPTOR Patient Acceptance of Health Care Explode All AND INREGISTER 9 MeSH DESCRIPTOR Patient Dropouts AND INREGISTER 10 (adhere* or nonadhere* or non‐adhere*):ti,ab,kw AND INREGISTER 11 (complian* or noncomplian* or non‐complian*):ti,ab,kw AND INREGISTER 12 refusal or refuse*:ti,ab,kw AND INREGISTER 13 concord*:ti,ab,kw AND INREGISTER 14 conform*:ti,ab,kw AND INREGISTER 15 accept*:ti,ab,kw AND INREGISTER 16 comply*:ti,ab,kw AND INREGISTER 17 #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 AND INREGISTER 18 #6 AND #17 AND INREGISTER	June 2019 (938) May 2020 (229)
CENTRAL (via Cochrane Register of Studies) Date of most recent search: 1 May 2020	1 MeSH DESCRIPTOR Pulmonary Disease, Chronic Obstructive Explode All AND CENTRAL:TARGET 2 MeSH DESCRIPTOR Bronchitis, Chronic AND CENTRAL:TARGET 3 ((obstruct*) near3 (pulmonary or lung* or airway* or airflow* or bronch* or respirat*)):ti,ab AND CENTRAL:TARGET 4 COPD:MISC1 AND CENTRAL:TARGET 5 (COPD OR COAD OR COBD OR AECOPD):TI,AB AND CENTRAL:TARGET 6 #1 OR #2 OR #3 OR #4 OR #5 AND CENTRAL:TARGET 7 MeSH DESCRIPTOR Patient Compliance Explode All AND CENTRAL:TARGET 8 MeSH DESCRIPTOR Patient Acceptance of Health Care Explode All AND CENTRAL:TARGET 9 MeSH DESCRIPTOR Patient Dropouts AND CENTRAL:TARGET 10 (adhere* or nonadhere* or non‐adhere*):ti,ab,kw AND CENTRAL:TARGET 11 (complian* or noncomplian* or non‐complian*):ti,ab,kw AND CENTRAL:TARGET 12 refusal or refuse*:ti,ab,kw AND CENTRAL:TARGET 13 concord*:ti,ab,kw AND CENTRAL:TARGET 14 conform*:ti,ab,kw AND CENTRAL:TARGET 15 accept*:ti,ab,kw AND CENTRAL:TARGET 16 comply*:ti,ab,kw AND CENTRAL:TARGET 17 #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 AND CENTRAL:TARGET 18 #6 AND #17 AND CENTRAL:TARGET	June 2019 (1715) May 2020 (564)
MEDLINE (Ovid) ALL Date of most recent search: 1 May 2020	1 exp Pulmonary Disease, Chronic Obstructive/ 2 Bronchitis, Chronic/ 3 (obstruct* adj3 (pulmonary or lung* or airway* or airflow* or bronch* or respirat*)).ti,ab. 4 (COPD or AECB or AECOPD).ti,ab. 5 or/1‐4 6 exp Patient Compliance/ 7 "Patient Acceptance of Health Care"/ 8 Patient Dropouts/ 9 (adhere* or nonadhere* or non‐adhere*).ti,ab. 10 (complian* or noncomplian* or non‐complian*).ti,ab. 11 (refusal or refuse*).ti,ab. 12 concord*.ti,ab. 13 conform*.ti,ab. 14 accept*.ti,ab. 15 comply.ti,ab. 16 or/6‐15 17 (treatment* or therapy or drug* or medicat* or pharmacolog*).tw. 18 16 and 17 19 5 and 18 20 (controlled clinical trial or randomized controlled trial).pt. 21 (randomized or randomised).ab,ti. 22 placebo.ab,ti. 23 dt.fs. 24 randomly.ab,ti. 25 trial.ab,ti. 26 groups.ab,ti. 27 or/20‐26 28 Animals/ 29 Humans/ 30 28 not (28 and 29) 31 27 not 30 32 19 and 31	June 2019 (1678) May 2020 (116)
Embase (Ovid) Date of most recent search: 1 May 2020	1 chronic obstructive lung disease/ 2 chronic bronchitis/ 3 (obstruct* adj3 (pulmonary or lung* or airway* or airflow* or bronch* or respirat*)).ti,ab. 4 (COPD or AECB or AECOPD).ti,ab. 5 or/1‐4 6 exp patient compliance/ 7 patient attitude/ 8 patient dropout/ 9 treatment refusal/ 10 (adhere* or nonadhere* or non‐adhere*).ti,ab. 11 (complian* or noncomplian* or non‐complian*).ti,ab. 12 (refusal or refuse*).ti,ab. 13 concord*.ti,ab. 14 conform*.ti,ab. 15 accept*.ti,ab. 16 comply.ti,ab. 17 or/6‐16 18 (treatment* or therapy or drug* or medicat* or pharmacolog*).tw. 19 17 and 18 20 5 and 19 21 Randomized Controlled Trial/ 22 randomization/ 23 controlled clinical trial/ 24 Double Blind Procedure/ 25 Single Blind Procedure/ 26 Crossover Procedure/ 27 (clinica$ adj3 trial$).tw. 28 ((singl$ or doubl$ or trebl$ or tripl$) adj3 (mask$ or blind$ or method$)).tw. 29 exp Placebo/ 30 placebo$.ti,ab. 31 random$.ti,ab. 32 ((control$ or prospectiv$) adj3 (trial$ or method$ or stud$)).tw. 33 (crossover$ or cross‐over$).ti,ab. 34 or/21‐33 35 exp animals/ or exp invertebrate/ or animal experiment/ or animal model/ or animal tissue/ or animal cell/ or nonhuman/ 36 human/ or normal human/ or human cell/ 37 35 and 36 38 35 not 37 39 34 not 38 40 20 and 39	June 2019 (2091) May 2020 (189)
ClinicalTrials.gov Date of most recent search: 1 May 2020	Study type: Interventional Condition: COPD Intervention: adherence OR compliance	June 2019 (53) May 2020 (6)
WHO trials portal Date of most recent search: 1 May 2020	Condition: COPD Intervention: adherence OR compliance	June 2019 (15) May 2020 (not searched)