Jarab 2012.

Study characteristics
Methods	Design: RCT Duration: 26 weeks Location: Jordan Setting: 1 outpatient COPD Clinic at the Royal Medical Services Hospital
Participants	Population: 133 participants with COPD randomly assigned to structured patient education (n = 66) or a control group (n = 67) Baseline characteristics COPD severity: moderate to severe Age (median): structured patient education 61 (IQR 14) years; control 64 (IQR 15) years % male: structured patient education 39.4%; control 41.8% FEV1 (mean) each group 1.1 (SD 0.5) L Inclusion criteria: people attending the outpatient COPD clinic at the Royal Medical Services, confirmed diagnosis of COPD by the hospital consultant for ≥ 1 year, aged > 35 years, FEV1 30–80% of the predicted normal value and hospital consultant agreement that the person was suitable for entering the trial Exclusion criteria: moderate‐to‐severe learning difficulties, mobility problems, confusion, disorientation or terminal illness, congestive heart failure or if patients attended a pulmonary rehabilitation programme or had consulted a pulmonary nurse or clinical pharmacist in the last 6 months
Interventions	Treatment arms Structured patient education: COPD and management of its symptoms, delivered by the clinical pharmacist; completed a medication table to discuss medication; booklet on the importance of simple exercises, symptoms control and the technique for expectoration; MI technique (for adherence) and referral to a special smoking cessation programme Control: no further details Allowed co‐medications: median 8 (IQR 5) in each group
Outcomes	Primary outcome: HRQoL improvement (SGRQ) Secondary outcomes: healthcare utilisation, COPD knowledge, medication adherence (self‐report)
Notes	Funding: Alzaytoonah University of Jordan Identifiers: DOI: 10.1007/s11096‐011‐9585‐z
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "Participants were randomly assigned to intervention and control groups via minimisation technique using MINIM software."
Allocation concealment (selection bias)	Unclear risk	Not reported.
Blinding of participants and personnel (performance bias) all outcomes	Unclear risk	Not reported.
Blinding of outcome assessment (detection bias) all outcomes	Unclear risk	Not reported.
Incomplete outcome data (attrition bias) all outcomes	Unclear risk	Attrition rate similar in both groups; however, there was no explanation of the people who withdrew, and the analysis was not ITT.
Selective reporting (reporting bias)	Unclear risk	Trial protocol was not found, unclear if outcomes were reported as planned.
Other bias	Low risk	None identified.