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. 2021 Aug 25;9:677697. doi: 10.3389/fcell.2021.677697

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Copyright © 2021 Zhao, Li, Gao, Li, Zhao and Yue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detailed characterization of malignant epithelial cells. (A) tSNE plot showing seven subgroups generated from malignant epithelial cells. (B) Heatmap showing the average expression of the top five markers across different subgroups. (C) The proportion of diverse subgroups across different sample origins. Differences in the activities of the TFs (D), HALLMARK pathway (E), and metabolic pathways (F) in each malignant epithelial subgroup.