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. 2021 Aug 25;9:677697. doi: 10.3389/fcell.2021.677697

FIGURE 6.

FIGURE 6

Potential mechanism of IFI6 promoting OC proliferation and cisplatin resistance may be related to the NF-κB pathway. (A) GSEA showing high-IFI6 groups is associated with G2M checkpoint in the TCGA OC dataset. (B,C) Effect of IFI6 on the colony formation of OC cells by plate colony formation assay. (D) CCK-8 assays demonstrating slower proliferation in IFI6 silent cells compared to the siCon cells. (E) Box plot illustrating higher IFI6 in the cisplatin-resistant and relapse group based on GEO datasets. (F) GSVA of WHITESIDE_CISPLATIN_RESISTANCE_UP in high- and low-IFI6 groups. (G) Cisplatin sensitivity in siCon and siIFI6 in SKOV3 cells. (H,I) Apoptotic cells by flow cytometry in control and siIFI6 in SKOV3 untreated or treated with cisplatin. The p-value of apoptosis (Q3) between the groups siCon+Cisplatin and siIFI6+Cisplatin is <0.05. (J) GSEA presenting higher IFI6 is associated with the NF-κB pathway. (K) Compared with control cells, the expressions of NFKB1, RELA, XIAP, and TNF are lower in siIFI6 cells in mRNA level.