TABLE 2.
Comparison of Baseline and Percentage Change Over 1 Year Between the Drug Naïve and the Already Treated Groups on Each Measure
| Measure | Rx Naïve MCI Baseline | Already Rx MCI Baseline | P | Rx Naïve MCI % change | Already Rx MCI % change | P |
|---|---|---|---|---|---|---|
| MMSE | 25.6 (1.6) | 26.3 (2.0) | 0.37 | 6.6% (14.2) | 8.4% (5) | 0.44 |
| HVLT (total items) | 14.4 (4.7) | 15.1 (6.2) | 0.78 | 3.7% (34.5) | −9.3% (39.6) | 0.72 |
| Rey CFT | 15.0 (5.2) | 21.2 (6.7) | 0.029* | −20.6% (58) | 17.2% (24.8) | 0.13 |
| BNT | 51.0 (10.4) | 49.7 (5.8) | 0.72 | −2.6% (11.3) | 8.8% (17.5) | 0.17 |
| VPS | ||||||
| (seconds) | 865.7 (409.1) | 729.8 (320.3) | 0.39 | 9.2% (41.1) | −34.3% (50.7) | 0.0377* |
| (# failed) † | 2.7 (2.2) | 1.6 (1.5) | 0.21 | 0.45 (1.9) | 1.4 (1.8) | 0.25 |
| Anagrams | ||||||
| (seconds) | 503.3 (246.1) | 449.9 (162.9) | 0.55 | −4.5% (27.9) | −20.3% (20.9) | 0.28 |
| (# failed) † | 3.3 (2.2) | 2.6 (1.5) | 0.43 | 0.64 (1.1) | 1.8 (1.9) | 0.11 |
| IADL | 11.2 (3.8) | 14.7 (5.2) | 0.11 | −73.4% (72) | −20.1% (33.9) | 0.09 |
Values are M ± SD unless otherwise noted. Baseline variables were compared using the Welch test or Fisher exact test for proportions, and percentage changes were compared using the Wilcoxon test.
Significant at P < 0.05.
The number failed is the difference (year 1 minus baseline) and not the percentage change, and P is the Welch test and not the Wilcoxon test.
BNT = Boston Naming Test. CFT = Complex Figure Test. HVLT = Hopkins Verbal Learning Test. IADL = Instrumental Activities of Daily Living. MCI = mild cognitive impairment. MMSE = Mini-Mental State Examination. Rx = prescription. VPS = visuospatial problem-solving task.