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Potential genomic treatments for Alport syndrome.COL4A3, COL4A4, and COL4A5 are transcribed into RNA in the nucleus. The RNA is then translated into type IV collagen protein isoforms. These type IV collagen isomers self-assemble into trimers in the endoplasmic reticulum. After they are processed into trimers, they are secreted into the GBM. There are a number of potential targets for rectification of this process in the setting of pathogenic variants in type IV collagen.
