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. 2021 Jul;32(7):1616–1629. doi: 10.1681/ASN.2020071029

Figure 1.

Figure 1.

Treatment with empagliflozin (EMPA) normalizes serum BNP concentration and slightly improves LV systolic function in nondiabetic rats with induced HF. Doppler echocardiography and quantitative determination of serum BNP were performed in sham and HF rats after 4 weeks of treatment with EMPA or no treatment. (A) The circulating levels of BNP and (B) the FAC of sham and HF rats treated with EMPA or untreated. The values represent individual measurements and the means ± SEM. ***P<0.001 versus sham; ††† P<0.001 versus sham + EMPA; # P=0.02 versus HF; ### P<0.001 versus HF.