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. 2021 Jul;32(7):1616–1629. doi: 10.1681/ASN.2020071029

Figure 2.

Figure 2.

Treatment with empagliflozin (EMPA) induces higher glycosuria, urinary flow, and sodium excretion in HF rats than in sham rats. Rats were individually placed into metabolic cages for 24-hour urine collection to measure glycosuria, urinary flow, and urinary sodium. Blood was collected from 12-hour fasting rats for the determination of blood glucose. (A) Glycosuria. (B) Blood glucose concentration. (C) Urinary sodium. (D) Urinary flow. Experiments were performed 4 weeks after treatment with EMPA or no treatment. The values represent individual measurements and the means ± SEM. **P=0.005 versus sham; ***P<0.001 versus sham; † P=0.02 versus sham + EMPA; ††† P<0.001 versus sham + EMPA; ### P<0.001 versus HF.