Table 2.
Characteristics of the Patients According to Anti-Spike Antibody Increase After the Third Vaccine Dose
| Ratio of Anti-S1 Antibody Titer, 3rd vs 2nd Dose |
P | |||
|---|---|---|---|---|
| <7.5 (n = 22) | 7.5-43 (n = 22) | >43 (n = 22) | ||
| Clinical characteristics | ||||
| Age, y | 63.5 [45.5-73.3] | 68.5 [54.3-76.0] | 68.5 [59.0-79.0] | 0.2 |
| Male sex | 16 (73%) | 16 (73%) | 13 (59%) | 0.7 |
| Body mass index, kg/m2 | 28.2 [23.8-30.6] | 26.7 [23.2-30.6] | 26.1 [22.2-30.8] | 0.7 |
| Diabetes | 6 (27%) | 10 (46%) | 6 (27%) | 0.4 |
| History of hemopathy | 1 (5%) | 2 (9%) | 1 (5%) | 0.9 |
| History of immunosuppressive therapy | 1 (5%) | 1 (5%) | 4 (18%) | 0.4 |
| HD as dialysis modality | 11 (50%) | 14 (64%) | 10 (46%) | 0.6 |
| Dialysis vintage, y | 3.0 [0.6-3.8] | 3.50 [1.3-7.0] | 4.00 [1.0-6.0] | 0.3 |
| Kt/V | 1.6 [1.1-1.9] | 1.5 [1.3-2.0] | 1.7 [1.4-1.9] | 0.8 |
| Biological parameters | ||||
| Lymphocytes, ×109/L | 1.3 [1.0-1.5] | 1.3 [1.0-1.6] | 1.1 [0.8-1.7] | 0.7 |
| Neutrophilic polymorphonuclear cells, ×109/L | 3.7 [2.6-4.4] | 4.4 [3.3-5.2] | 3.7 [3.0-4.9] | 0.3 |
| Gamma globulin, g/L | 10.3 [8.3-14.8] | 9.0 [8.1-10.5] | 9.8 [7.3-12.3] | 0.6 |
| Serum albumin, g/L | 3.8 [3.5-4.0] | 3.9 [3.7-4.2] | 3.5 [3.3-3.9] | 0.2 |
| Serum prealbumin, g/L | 34 [30-41] | 37 [31-42] | 32 [27-38] | 0.2 |
| C-reactive protein, mg/L | 2.1 [1.0-4.5] | 1.7 [0.8-3.3] | 2.2 [1.0-3.8] | 0.9 |
| Humoral response | ||||
| Anti-S1 Ab after 2nd dose, AU/mL | 1,718 [963-5,165] | 347 [104-478] | 94 [30-237] | <0.001 |
| After the 3rd dose | ||||
| Interval between 2nd and 3rd doses, d | 59 [36-67] | 73 [61-78] | 74 [72-79] | <0.001 |
| Anti-S1 Ab after 3rd dose, AU/mL | 4,533 [1,950-11,351] | 7,237 [2,602-9,384] | 11,305 [5,800-15,027] | 0.08 |
| Ratio of Ab after 3rd vs 2nd dose | 1.6 [1.1-2.3] | 23.0 [13.7-29.3] | 99.9 [64.8-247.8] | <0.001 |
Results are shown as median [interquartile range] for continuous variables, or as number of patients (percentage) for categorical variables. Kruskal-Wallis test and Fisher exact test were used to compare continuous and categorical variables according to the dialysis modality. Abbreviations: Ab, antibody; AU, arbitrary unit; HD, hemodialysis; S1, spike protein S1.